PEX5L

Across TCGA patient cohorts, PEX5L mutation is significantly associated with the RNA expression of many other genes, with 3,859 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PEX5L-associated genes across cancer lineages are MIR1268B, RN7SL248P, and RNA5SP509. Each is linked with PEX5L in more than 3 cancer types. Because this analysis shows association rather than direction, both PEX5L-to-partner and partner-to-PEX5L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR1268B grouped by PEX5L-low versus PEX5L-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PEX5L→partner) and Y-score (partner→PEX5L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR1268B →	+0.421	+2.467	<.001	.001	3	4
CESC	RN7SL248P →	+0.070	+4.777	<.001	.002	3	3
HNSC	RNA5SP509 →	+0.083	+4.778	<.001	.002	3	3
LUAD	FGF21 →	+0.395	+3.669	<.001	<.001	3	3
HNSC	RPL35AP3 →	+0.081	+2.633	.002	.009	3	3
SKCM	DEPDC4 →	+0.275	+2.616	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,859 associations by consensus.

MIR1268B by PEX5L expression — SKCM

Explore this box plot interactively →