PEX5L

Across TCGA pan-cancer cohorts, PEX5L RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated PEX5L data layer compared with 10 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher PEX5L RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PEX5L expression acts as an unfavorable survival marker, although some lineages such as MESO and BRCA show a favorable association.

BLCA, MESO, and KIRP are the cancer types where PEX5L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Quartile	II,III,IV	0.366	0.580	<.001	101	view →
MESO	OS	Quartile	All	0.697	0.334	<.001	74	view →
KIRP	DFS	Median	All	0.515	0.683	<.001	73	view →
UCEC	DFS	Tertile	All	0.554	0.729	.001	52	view →
HNSC	OS	Tertile	All	0.447	0.705	.001	41	view →
COAD	DFS	Quartile	IV	0.234	0.602	<.001	39	view →
BRCA	DFS	Quartile	III,IV	0.934	0.765	.001	37	view →
KIRC	DFS	Tertile	All	0.520	0.738	<.001	34	view →
LIHC	DFS	Tertile	All	0.397	0.619	<.001	32	view →
UVM	DFS	Median	III,IV	0.183	0.824	.001	30	view →
LUAD	DFS	Tertile	II,III,IV	0.596	0.817	.010	26	view →
READ	DFS	Median	IV	0.228	0.709	<.001	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

PEX5L–BLCA (DFS)

Open the BLCA breakdown →