PEX5L

Across TCGA pan-cancer cohorts, PEX5L RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PEX5L’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PEX5L RNA is repressed in tumor relative to normal tissue. In most cancer types PEX5L is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and BRCA are the cancer types where PEX5L tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PEX5L RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	−0.237	<.001	10	view →
KICH	Female	All	−0.251	<.001	9	view →
BRCA	All	II,III,IV	+0.439	<.001	6	view →
LIHC	Female	All	+0.038	<.001	5	view →
PAAD	Female	All	−0.120	.003	4	view →
KIRP	Female	All	−0.141	<.001	3	view →
CHOL	All	II,III,IV	+0.115	.030	2	view →
UCEC	All	All	−0.110	.041	2	view →
LUAD	Female	II,III,IV	−0.078	.037	1	view →
READ	Female	All	−0.062	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PEX5L–THCA

Open the THCA breakdown →