PDZK1

Across TCGA patient cohorts, PDZK1 mutation is significantly associated with the RNA expression of many other genes, with 1,584 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDZK1-associated genes across cancer lineages are RNU1-35P, SNORA10B, and USP9YP10. Each is linked with PDZK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDZK1-to-partner and partner-to-PDZK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-35P grouped by PDZK1-low versus PDZK1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDZK1→partner) and Y-score (partner→PDZK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU1-35P →	+0.602	+5.212	<.001	.007	3	2
COAD	SNORA10B →	+1.044	+5.693	<.001	.003	3	2
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	2
SKCM	RNU7-63P →	+0.538	+4.979	<.001	.009	3	1
SKCM	RNU7-80P →	+1.127	+5.680	<.001	.003	3	1
LIHC	OR10V1 →	+0.058	+5.902	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,584 associations by consensus.

RNU1-35P by PDZK1 expression — COAD

Explore this box plot interactively →