PDZK1

Across TCGA pan-cancer cohorts, PDZK1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of PDZK1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where PDZK1 RNA is repressed in tumor relative to normal tissue. In most cancer types PDZK1 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

KICH, BLCA, and LIHC are the cancer types where PDZK1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PDZK1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	III,IV	−6.153	<.001	11	view →
BLCA	All	III,IV	+0.319	.001	10	view →
LIHC	Male	II,III,IV	+1.379	<.001	7	view →
KIRP	All	III,IV	−0.985	.011	5	view →
COAD	All	II,III,IV	−0.950	.001	5	view →
HNSC	Male	III,IV	+0.876	.007	5	view →
KIRC	Male	All	−0.669	.007	2	view →
READ	All	All	−1.291	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

PDZK1–KICH

Open the KICH breakdown →