PDIA6

Across TCGA patient cohorts, PDIA6 mutation is significantly associated with the RNA expression of many other genes, with 1,082 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PDIA6-associated genes across cancer lineages are RN7SL149P, LARP7P2, and LCE1A. Each is linked with PDIA6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PDIA6-to-partner and partner-to-PDIA6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL149P grouped by PDIA6-low versus PDIA6-high in PRAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDIA6→partner) and Y-score (partner→PDIA6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	RN7SL149P →	+0.151	+5.897	<.001	.002	3	2
CESC	LARP7P2 →	+0.371	+5.127	<.001	.001	3	2
KIRC	LCE1A →	+0.480	+5.985	<.001	.002	3	2
KIRC	SNORD109B →	+0.349	+5.579	.003	.004	3	2
BLCA	RN7SL571P →	+0.166	+5.455	<.001	.001	3	2
HNSC	RNU6-458P →	+0.343	+7.954	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,082 associations by consensus.

RN7SL149P by PDIA6 expression — PRAD

Explore this box plot interactively →