PDIA6

Across TCGA pan-cancer cohorts, PDIA6 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of PDIA6’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PDIA6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PDIA6 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, BLCA, and KIRC are the cancer types where PDIA6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PDIA6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.640	<.001	12	view →
BLCA	Female	All	+1.226	<.001	11	view →
KIRC	Female	III,IV	+0.747	<.001	11	view →
THCA	Male	III,IV	−1.512	<.001	10	view →
COAD	Male	III,IV	+0.996	<.001	10	view →
LUAD	Male	All	+1.091	<.001	9	view →
KICH	Female	II,III,IV	−2.219	<.001	8	view →
LUSC	Female	All	+1.367	<.001	8	view →
LIHC	Male	All	+1.173	<.001	7	view →
STAD	Male	II,III,IV	+1.024	<.001	6	view →
UCEC	All	II,III,IV	+0.927	.011	6	view →
BRCA	All	All	+0.528	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

PDIA6–HNSC

Open the HNSC breakdown →