PDE5A

Across TCGA cell cohorts, PDE5A mutation is significantly associated with the RNA expression of many other genes, with 483 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PDE5A-associated genes across cancer lineages are SPACA1, KRTAP21-3, and DDX17. Each is linked with PDE5A in more than 1 cancer types. Because this analysis shows association rather than direction, both PDE5A-to-partner and partner-to-PDE5A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPACA1 grouped by PDE5A-low versus PDE5A-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PDE5A→partner) and Y-score (partner→PDE5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SPACA1 →	+0.023	+5.285	<.001	.003	3	1
STOMACH	KRTAP21-3 →	+0.513	+5.285	<.001	.003	3	1
LARGE_INTESTINE	DDX17 →	+0.715	+3.212	.001	.006	3	1
LARGE_INTESTINE	RNF125 →	+1.155	+3.212	<.001	.006	3	1
LARGE_INTESTINE	NISCH →	+0.885	+3.082	<.001	.007	3	1
LARGE_INTESTINE	CCP110 →	+0.688	+3.212	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 483 associations by consensus.

SPACA1 by PDE5A expression — STOMACH

Explore this box plot interactively →