PDE5A

Across TCGA pan-cancer cohorts, PDE5A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PDE5A’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PDE5A RNA is repressed in tumor relative to normal tissue. In most cancer types PDE5A is over-expressed in tumor, although a few such as BLCA and COAD show the opposite, repressed pattern.

BLCA, COAD, and THCA are the cancer types where PDE5A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PDE5A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	−2.760	<.001	11	view →
COAD	Female	All	−1.609	<.001	11	view →
THCA	Male	III,IV	+2.302	<.001	10	view →
LUSC	All	III,IV	−2.268	<.001	9	view →
READ	All	All	−2.200	<.001	7	view →
LUAD	Female	III,IV	−2.054	<.001	7	view →
UCEC	All	All	−2.255	<.001	6	view →
BRCA	All	All	−1.074	<.001	6	view →
LIHC	All	All	+0.503	<.001	5	view →
CHOL	All	All	+2.634	<.001	3	view →
STAD	All	All	−0.900	.018	3	view →
PRAD	All	All	−0.855	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PDE5A–BLCA

Open the BLCA breakdown →