PCYT1A

Across TCGA patient cohorts, PCYT1A mutation is significantly associated with the RNA expression of many other genes, with 921 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PCYT1A-associated genes across cancer lineages are MTND6P14, DNAJC19P7, and RN7SL132P. Each is linked with PCYT1A in more than 1 cancer types. Because this analysis shows association rather than direction, both PCYT1A-to-partner and partner-to-PCYT1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND6P14 grouped by PCYT1A-low versus PCYT1A-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PCYT1A→partner) and Y-score (partner→PCYT1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MTND6P14 →	+0.023	+3.993	<.001	.008	3	2
SKCM	DNAJC19P7 →	+0.149	+2.577	<.001	.007	3	2
SKCM	RN7SL132P →	+0.044	+3.993	<.001	.008	3	2
CESC	RNU6-628P →	+0.441	+3.914	<.001	.007	3	2
COAD	RPL27AP4 →	+0.170	+3.588	.008	.007	3	2
LIHC	LINC01616 →	+0.028	+5.758	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 921 associations by consensus.

MTND6P14 by PCYT1A expression — SKCM

Explore this box plot interactively →