PCYT1A

Across TCGA pan-cancer cohorts, PCYT1A RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PCYT1A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PCYT1A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PCYT1A is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, LIHC, and LUSC are the cancer types where PCYT1A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PCYT1A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.100	<.001	12	view →
LIHC	Female	II,III,IV	+0.982	<.001	9	view →
LUSC	Female	All	+1.182	<.001	8	view →
KIRP	All	II,III,IV	+0.449	<.001	8	view →
KIRC	Female	All	+0.446	<.001	8	view →
THCA	All	All	−0.258	<.001	8	view →
CHOL	Male	All	+1.708	<.001	5	view →
KICH	All	All	−0.606	<.001	4	view →
COAD	Female	All	−0.365	.008	4	view →
UCEC	All	All	−0.340	.044	2	view →
STAD	Male	III,IV	+0.926	.026	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PCYT1A–HNSC

Open the HNSC breakdown →