PARP9

Across TCGA cell cohorts, PARP9 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PARP9-associated genes across cancer lineages are GZMK, FOXR2, and SH3GL2. Each is linked with PARP9 in more than 1 cancer types. Because this analysis shows association rather than direction, both PARP9-to-partner and partner-to-PARP9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GZMK grouped by PARP9-low versus PARP9-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP9→partner) and Y-score (partner→PARP9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GZMK →	+0.006	+5.614	<.001	.002	3	1
PANCREAS	FOXR2 →	+0.006	+5.000	<.001	.006	3	1
LARGE_INTESTINE	SH3GL2 →	+1.065	+3.252	.008	.009	3	1
LARGE_INTESTINE	KCND3 →	+0.356	+3.285	<.001	.007	3	1
LARGE_INTESTINE	TBC1D3 →	+0.053	+2.688	<.001	.008	3	1
BLOOD_Leukemia	OPRM1 →	+0.022	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

GZMK by PARP9 expression — PANCREAS

Explore this box plot interactively →