PARP15

Across TCGA patient cohorts, PARP15 mutation is significantly associated with the RNA expression of many other genes, with 4,017 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PARP15-associated genes across cancer lineages are CXCR6, IL12RB1, and CLUH. Each is linked with PARP15 in more than 2 cancer types. Because this analysis shows association rather than direction, both PARP15-to-partner and partner-to-PARP15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CXCR6 grouped by PARP15-low versus PARP15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARP15→partner) and Y-score (partner→PARP15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CXCR6 →	+0.838	+2.868	<.001	<.001	3	3
UCEC	IL12RB1 →	+0.572	+2.711	<.001	.003	3	3
UCEC	CLUH →	+0.458	+2.425	<.001	.001	3	3
BRCA	RSL24D1P9 →	+0.061	+2.937	.004	.006	3	3
LUAD	SAGE3P →	+0.011	+5.748	<.001	.001	3	3
BRCA	MIR6780B →	+0.301	+3.119	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,017 associations by consensus.

CXCR6 by PARP15 expression — UCEC

Explore this box plot interactively →