PARP15

Across TCGA pan-cancer cohorts, PARP15 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated PARP15 data layer compared with 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher PARP15 RNA is associated with better overall survival. In most high-consensus cancer types, elevated PARP15 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and LUAD are the cancer types where PARP15 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.726	0.592	<.001	147	view →
SKCM	OS	Median	All	0.427	0.249	<.001	137	view →
LUAD	OS	Median	All	0.754	0.623	<.001	106	view →
LGG	OS	Median	All	0.350	0.526	<.001	54	view →
CESC	DFS	Median	All	0.624	0.456	.006	50	view →
UCEC	DFS	Median	III,IV	0.676	0.430	.009	30	view →
BRCA	OS	Median	All	0.975	0.949	.005	28	view →
LAML	DFS	Median	All	0.442	0.696	.009	24	view →
KIRC	DFS	Median	All	0.526	0.727	.002	24	view →
ESCA	DFS	Median	III,IV	0.445	0.217	<.001	23	view →
STAD	OS	Median	II,III,IV	0.725	0.367	.011	18	view →
BLCA	OS	Tertile	III,IV	0.747	0.615	.012	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

PARP15–HNSC (OS)

Open the HNSC breakdown →