PARD6A

Across TCGA patient cohorts, PARD6A mutation is significantly associated with the RNA expression of many other genes, with 100 significant associations in total. BLCA shows the largest number of these associations.

The most reproducible PARD6A-associated genes across cancer lineages are RN7SL248P, SNORD96B, and HMGB4. Each is linked with PARD6A in more than 1 cancer types. Because this analysis shows association rather than direction, both PARD6A-to-partner and partner-to-PARD6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL248P grouped by PARD6A-low versus PARD6A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PARD6A→partner) and Y-score (partner→PARD6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL248P →	+0.102	+4.137	<.001	.008	3	2
BLCA	SNORD96B →	+0.375	+3.716	<.001	<.001	3	2
CESC	HMGB4 →	+0.018	+5.306	<.001	.006	3	1
CESC	RNU6-522P →	+0.333	+5.418	<.001	.005	3	1
CESC	CCNJP1 →	+0.037	+5.669	<.001	.003	3	1
UCEC	RNU6-97P →	+0.744	+3.144	.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 100 associations by consensus.

RN7SL248P by PARD6A expression — UCEC

Explore this box plot interactively →