PARD6A

Across TCGA pan-cancer cohorts, PARD6A RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PARD6A’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PARD6A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PARD6A is over-expressed in tumor, although a few such as KIRC and KICH show the opposite, repressed pattern.

COAD, KIRC, and KICH are the cancer types where PARD6A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PARD6A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	+1.819	<.001	11	view →
KIRC	Male	II,III,IV	−1.451	<.001	11	view →
KICH	Male	All	−1.514	<.001	10	view →
THCA	Male	All	−0.737	<.001	8	view →
BRCA	All	All	+0.389	<.001	6	view →
LUSC	Male	All	−0.640	<.001	5	view →
LIHC	Male	All	+0.599	<.001	5	view →
STAD	Male	II,III,IV	+0.880	.008	3	view →
ESCA	Female	All	+1.250	.002	2	view →
CHOL	All	All	+0.874	.006	2	view →
HNSC	Female	III,IV	−0.768	.013	2	view →
PRAD	All	All	+0.336	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PARD6A–COAD

Open the COAD breakdown →