PAK2

Across TCGA patient cohorts, PAK2 mutation is significantly associated with the RNA expression of many other genes, with 2,148 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PAK2-associated genes across cancer lineages are LCE1D, RN7SL248P, and FAM27B. Each is linked with PAK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PAK2-to-partner and partner-to-PAK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCE1D grouped by PAK2-low versus PAK2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PAK2→partner) and Y-score (partner→PAK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LCE1D →	+0.680	+5.571	<.001	.002	3	2
UCEC	RN7SL248P →	+0.057	+3.137	<.001	.005	3	2
SKCM	FAM27B →	+0.115	+4.282	.001	.009	3	2
COAD	RN7SL598P →	+0.564	+5.516	<.001	.004	3	2
COAD	ANKRD33B-AS1 →	+0.268	+5.893	.002	.002	3	2
COAD	MIR4298 →	+0.960	+5.790	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,148 associations by consensus.

LCE1D by PAK2 expression — BRCA

Explore this box plot interactively →