PAK2

Across TCGA pan-cancer cohorts, PAK2 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PAK2 data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher PAK2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PAK2 expression acts as an unfavorable survival marker, although some lineages such as KIRC and THYM show a favorable association.

MESO, KIRC, and ACC are the cancer types where PAK2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.272	0.486	<.001	78	view →
KIRC	DFS	Median	All	0.733	0.508	<.001	74	view →
ACC	DFS	Median	All	0.218	0.650	<.001	67	view →
LIHC	OS	Tertile	All	0.693	0.848	<.001	51	view →
PAAD	OS	Quartile	All	0.232	0.616	<.001	40	view →
KIRP	DFS	Quartile	All	0.784	0.945	.004	32	view →
KICH	DFS	Tertile	II,III,IV	0.378	0.891	.002	30	view →
BLCA	DFS	Quartile	All	0.188	0.533	.001	26	view →
HNSC	OS	Tertile	All	0.616	0.811	.004	19	view →
THCA	DFS	Quartile	All	0.773	0.963	.002	17	view →
LUAD	OS	Tertile	All	0.217	0.414	.005	17	view →
UCEC	DFS	Tertile	All	0.561	0.716	.009	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PAK2–MESO (OS)

Open the MESO breakdown →