OTUD6B

Across TCGA patient cohorts, OTUD6B mutation is significantly associated with the RNA expression of many other genes, with 859 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTUD6B-associated genes across cancer lineages are MIR4540, RN7SL248P, and RNU6-73P. Each is linked with OTUD6B in more than 1 cancer types. Because this analysis shows association rather than direction, both OTUD6B-to-partner and partner-to-OTUD6B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4540 grouped by OTUD6B-low versus OTUD6B-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTUD6B→partner) and Y-score (partner→OTUD6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MIR4540 →	+0.581	+5.584	<.001	.002	3	2
LUAD	RN7SL248P →	+0.136	+5.584	<.001	.002	3	2
UCEC	RNU6-73P →	+0.167	+3.226	.003	.005	3	2
UCEC	LINC01809 →	+0.153	+2.899	<.001	.003	3	2
COAD	H2BC2P →	+0.219	+4.917	<.001	.003	3	2
READ	CDRT15P8 →	+0.092	+4.421	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 859 associations by consensus.

MIR4540 by OTUD6B expression — LUAD

Explore this box plot interactively →