OTUD6B

Across TCGA pan-cancer cohorts, OTUD6B RNA is linked to patient survival in 30 of 34 cancer types, making it the most broadly survival-associated OTUD6B data layer compared with 4 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher OTUD6B RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated OTUD6B expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

UVM, KIRP, and LIHC are the cancer types where OTUD6B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	III,IV	0.170	0.914	<.001	57	view →
KIRP	DFS	Tertile	All	0.616	0.799	<.001	54	view →
LIHC	DFS	Quartile	All	0.438	0.657	<.001	45	view →
MESO	OS	Tertile	All	0.257	0.500	.003	43	view →
KICH	DFS	Quartile	All	0.472	1.000	<.001	41	view →
BRCA	OS	Tertile	II,III,IV	0.429	0.658	<.001	33	view →
KIRC	DFS	Quartile	All	0.857	0.654	.003	25	view →
UCS	DFS	Tertile	IV	0.936	0.364	.024	24	view →
UCEC	DFS	Tertile	All	0.540	0.770	.001	20	view →
LUAD	OS	Median	All	0.242	0.438	.003	19	view →
ESCA	DFS	Median	II,III,IV	0.404	0.570	.016	19	view →
SARC	OS	Tertile	All	0.427	0.773	.001	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 30 lineages.

OTUD6B–UVM (DFS)

Open the UVM breakdown →