OTOAP1

Across TCGA patient cohorts, OTOAP1 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTOAP1-associated genes across cancer lineages are MIR3689B, MIR369, and NMS. Each is linked with OTOAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both OTOAP1-to-partner and partner-to-OTOAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3689B grouped by OTOAP1-low versus OTOAP1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTOAP1→partner) and Y-score (partner→OTOAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR3689B →	+0.338	+6.219	<.001	<.001	3	2
SKCM	MIR369 →	+0.625	+7.228	<.001	<.001	3	1
SKCM	NMS →	+0.912	+4.771	<.001	.006	3	1
SKCM	MTND4P18 →	+0.068	+5.199	<.001	.003	3	1
SKCM	MIR6817 →	+0.415	+5.080	<.001	.004	3	1
LUSC	RNU6-259P →	+0.391	+7.924	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

MIR3689B by OTOAP1 expression — SKCM

Explore this box plot interactively →