OTOAP1

Across TCGA pan-cancer cohorts, OTOAP1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of OTOAP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where OTOAP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OTOAP1 is over-expressed in tumor, although a few such as LUSC and PAAD show the opposite, repressed pattern.

KIRC, KIRP, and STAD are the cancer types where OTOAP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OTOAP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.651	<.001	12	view →
KIRP	Male	All	+0.853	<.001	9	view →
STAD	All	II,III,IV	+0.299	<.001	7	view →
HNSC	All	III,IV	+0.157	.003	7	view →
THCA	All	All	+0.138	<.001	7	view →
LIHC	All	II,III,IV	+0.206	<.001	5	view →
LUSC	All	All	−0.326	<.001	4	view →
UCEC	All	All	+0.108	.001	4	view →
PAAD	All	All	−0.662	.045	2	view →
CHOL	All	All	+0.263	.013	2	view →
COAD	Male	All	+0.134	.020	2	view →
PRAD	All	All	+0.088	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

OTOAP1–KIRC

Open the KIRC breakdown →