OR52E4

Across TCGA cell cohorts, OR52E4 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible OR52E4-associated genes across cancer lineages are OR6C75, CCR8, and CYLC1. Each is linked with OR52E4 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR52E4-to-partner and partner-to-OR52E4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6C75 grouped by OR52E4-low versus OR52E4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR52E4→partner) and Y-score (partner→OR52E4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR6C75 →	+0.018	+4.681	<.001	.003	3	2
SOFT_TISSUE	CCR8 →	+0.022	+5.369	<.001	.004	3	1
LARGE_INTESTINE	CYLC1 →	+0.004	+4.437	<.001	.004	3	1
LARGE_INTESTINE	OR52B6 →	+0.096	+3.920	<.001	.005	3	1
LARGE_INTESTINE	OR11G2 →	+0.008	+4.437	<.001	.004	3	1
LUNG_NSCLC_LUAD	MYH8 →	+0.005	+4.189	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

OR6C75 by OR52E4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →