OR4X2

Across TCGA cell cohorts, OR4X2 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible OR4X2-associated genes across cancer lineages are VAX1, OR14K1, and PYGO1. Each is linked with OR4X2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OR4X2-to-partner and partner-to-OR4X2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VAX1 grouped by OR4X2-low versus OR4X2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OR4X2→partner) and Y-score (partner→OR4X2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	VAX1 →	+0.798	+3.782	<.001	.002	3	1
LARGE_INTESTINE	OR14K1 →	+0.058	+3.700	<.001	.009	3	1
LARGE_INTESTINE	PYGO1 →	+0.905	+3.539	.004	.004	3	1
LARGE_INTESTINE	C14orf180 →	+0.085	+3.155	.007	.008	3	1
LARGE_INTESTINE	GAB4 →	+0.012	+3.562	<.001	.002	3	1
LARGE_INTESTINE	SMIM28 →	+0.011	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

VAX1 by OR4X2 expression — LARGE_INTESTINE

Explore this box plot interactively →