Q-omics provides the consensus-scored OR4E1 profile across patient tissues and cancer cell-line models. OR4E1 expression is associated with patient survival in 16 of 34 cancer types, with the highest sampling consensus in BRCA. Among the 18 cancer types available for tumor–normal comparison, OR4E1 is differentially expressed in 2, with the highest sampling consensus in THCA. Additionally, OR4E1 RNA expression shows 5,910 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight BRCA, THCA, and STAD as cancer lineages where OR4E1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for OR4E1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes OR4E1 survival associations across molecular data types. OR4E1 RNA expression shows survival associations in the most cancer types (16). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible OR4E1 RNA expression–survival associations across cancer types. High OR4E1 expression shows unfavorable associations in BRCA, DLBC, SARC and COAD, but favorable associations in OV and ESCA. The BRCA Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .002). Together, the overview and detailed table identify BRCA as the clearest survival context for OR4E1 RNA expression.
This table summarizes OR4E1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 2. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for OR4E1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. OR4E1 shows lower tumor expression in THCA and COAD. The THCA box plot shows higher OR4E1 RNA expression in normal versus tumor tissue (log2 FC = −0.010, t-test p = .047).
This table shows molecular features associated with OR4E1 in patient tissues and cancer cell lines. In patient samples, OR4E1 shows the broadest associations at the RNA and protein expression levels, with STAD recurring as the lineage with the largest associated feature set. In cancer cell lines, OR4E1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BONE.
