OR4E1

Across TCGA pan-cancer cohorts, OR4E1 RNA is linked to patient survival in 16 of 34 cancer types, making it the most broadly survival-associated OR4E1 data layer.

The strongest signal is observed in lymphoid neoplasm diffuse large b-cell lymphoma (DLBC), where higher OR4E1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated OR4E1 expression acts as an unfavorable survival marker, although some lineages such as ESCA and OV show a favorable association.

DLBC, BRCA, and SARC are the cancer types where OR4E1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
DLBC	DFS	Tertile	IV	0.120	0.683	.001	36	view →
BRCA	OS	Tertile	All	0.893	0.965	.002	36	view →
SARC	OS	Tertile	All	0.153	0.600	<.001	36	view →
ESCA	DFS	Tertile	III,IV	0.552	0.250	.026	30	view →
OV	OS	Tertile	All	0.492	0.304	.021	30	view →
COAD	OS	Tertile	IV	0.218	0.718	<.001	27	view →
SKCM	DFS	Tertile	IV	0.036	0.433	<.001	18	view →
THCA	DFS	Tertile	III,IV	0.145	0.765	.003	18	view →
LUSC	OS	Tertile	II,III,IV	0.250	0.778	.007	18	view →
CESC	OS	Tertile	II,III,IV	0.113	0.546	.048	18	view →
LIHC	DFS	Tertile	III,IV	1.000	0.148	.039	18	view →
LGG	DFS	Tertile	All	0.249	0.753	.013	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 16 lineages.

OR4E1–DLBC (DFS)

Open the DLBC breakdown →