NXF5

Across TCGA cell cohorts, NXF5 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible NXF5-associated genes across cancer lineages are SULT6B1, RBMY1F, and SPINK14. Each is linked with NXF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both NXF5-to-partner and partner-to-NXF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SULT6B1 grouped by NXF5-low versus NXF5-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NXF5→partner) and Y-score (partner→NXF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SULT6B1 →	+1.618	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	RBMY1F →	+0.221	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	SPINK14 →	+0.353	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	RBMY1B →	+0.734	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

SULT6B1 by NXF5 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →