NXF5

Across TCGA pan-cancer cohorts, NXF5 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated NXF5 data layer compared with 9 for mutation status.

The strongest signal is observed in uterine carcinosarcoma (UCS), where higher NXF5 RNA is associated with better overall survival. In most high-consensus cancer types, elevated NXF5 expression acts as an unfavorable survival marker, although some lineages such as UCS and ACC show a favorable association.

UCS, ACC, and ESCA are the cancer types where NXF5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCS	OS	Tertile	II,III,IV	0.791	0.251	.003	76	view →
ACC	DFS	Median	All	0.657	0.255	<.001	62	view →
ESCA	OS	Tertile	III,IV	0.713	0.316	.005	49	view →
PAAD	DFS	Quartile	All	0.556	0.204	<.001	48	view →
KIRP	DFS	Tertile	IV	0.764	0.043	.011	39	view →
LGG	DFS	Median	All	0.315	0.468	<.001	36	view →
LAML	DFS	Median	All	0.249	0.476	.005	36	view →
UVM	OS	Tertile	All	0.831	0.497	.017	29	view →
THCA	OS	Median	II,III,IV	0.958	0.994	.006	27	view →
LIHC	DFS	Quartile	II,III,IV	0.342	0.180	.011	18	view →
MESO	DFS	Tertile	III,IV	0.234	0.417	.006	15	view →
LUAD	OS	Quartile	III,IV	0.750	0.429	.023	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

NXF5–UCS (OS)

Open the UCS breakdown →