NXF5

Across TCGA pan-cancer cohorts, NXF5 RNA differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of NXF5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NXF5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NXF5 is over-expressed in tumor, although a few such as LUAD and THCA show the opposite, repressed pattern.

KIRC, LUAD, and BRCA are the cancer types where NXF5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NXF5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	+0.136	<.001	8	view →
LUAD	All	III,IV	−0.098	<.001	8	view →
BRCA	All	II,III,IV	+0.098	.001	6	view →
THCA	Female	II,III,IV	−0.092	.002	6	view →
KIRP	Female	II,III,IV	−0.077	.011	3	view →
LUSC	Male	All	−0.052	<.001	3	view →
BRCA	All	IV	−0.065	.005	2	view →
LIHC	Male	II,III,IV	+0.034	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 7 lineages.

NXF5–KIRC

Open the KIRC breakdown →