NSUN5

Across TCGA patient cohorts, NSUN5 mutation is significantly associated with the RNA expression of many other genes, with 338 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NSUN5-associated genes across cancer lineages are RBM22P13, ECM1P1, and LINC02022. Each is linked with NSUN5 in more than 1 cancer types. Because this analysis shows association rather than direction, both NSUN5-to-partner and partner-to-NSUN5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBM22P13 grouped by NSUN5-low versus NSUN5-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSUN5→partner) and Y-score (partner→NSUN5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RBM22P13 →	+0.059	+5.099	<.001	.008	3	2
LUAD	ECM1P1 →	+0.058	+5.044	<.001	.009	3	2
HNSC	LINC02022 →	+0.661	+4.388	<.001	.001	3	2
HNSC	RN7SL288P →	+0.094	+3.517	.002	.008	3	2
HNSC	HMGN1P17 →	+1.060	+4.388	<.001	.001	3	2
SKCM	MIR365A →	+0.220	+3.232	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 338 associations by consensus.

RBM22P13 by NSUN5 expression — LUAD

Explore this box plot interactively →