NSUN5

Across TCGA pan-cancer cohorts, NSUN5 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of NSUN5’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where NSUN5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NSUN5 is over-expressed in tumor.

COAD, KIRP, and LUAD are the cancer types where NSUN5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NSUN5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	+1.430	<.001	12	view →
KIRP	All	IV	+1.712	<.001	11	view →
LUAD	Female	III,IV	+1.185	<.001	11	view →
HNSC	Male	IV	+1.334	<.001	10	view →
LIHC	Male	II,III,IV	+1.537	<.001	9	view →
STAD	Male	II,III,IV	+1.346	<.001	9	view →
BLCA	All	All	+0.830	<.001	9	view →
LUSC	Male	II,III,IV	+1.145	<.001	7	view →
KIRC	All	All	+0.248	.002	7	view →
UCEC	All	III,IV	+0.636	.002	6	view →
BRCA	All	III,IV	+0.631	<.001	6	view →
CHOL	Female	All	+2.383	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

NSUN5–COAD

Open the COAD breakdown →