NSUN5

Across TCGA pan-cancer cohorts, NSUN5 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated NSUN5 data layer compared with 5 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher NSUN5 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NSUN5 expression acts as an unfavorable survival marker, although some lineages such as THYM and SCLC show a favorable association.

KIRC, ACC, and KICH are the cancer types where NSUN5 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.553	0.696	<.001	144	view →
ACC	DFS	Median	All	0.213	0.738	<.001	87	view →
KICH	DFS	Median	II,III,IV	0.558	1.000	.003	85	view →
LIHC	DFS	Median	All	0.463	0.618	<.001	72	view →
COAD	DFS	Tertile	II,III,IV	0.383	0.564	.002	62	view →
MESO	DFS	Median	III,IV	0.280	0.448	.009	42	view →
LGG	DFS	Median	All	0.665	0.805	<.001	41	view →
UCEC	DFS	Tertile	All	0.777	0.874	.008	32	view →
THYM	OS	Median	II,III,IV	0.962	0.688	.004	28	view →
PRAD	DFS	Median	All	0.899	0.964	<.001	22	view →
GBM	OS	Median	All	0.320	0.508	<.001	18	view →
SCLC	DFS	Median	All	0.691	0.412	.007	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

NSUN5–KIRC (OS)

Open the KIRC breakdown →