NSMCE1

Across TCGA patient cohorts, NSMCE1 mutation is significantly associated with the RNA expression of many other genes, with 547 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NSMCE1-associated genes across cancer lineages are VCY, FAM247B, and MYCLP1. Each is linked with NSMCE1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NSMCE1-to-partner and partner-to-NSMCE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VCY grouped by NSMCE1-low versus NSMCE1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NSMCE1→partner) and Y-score (partner→NSMCE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	VCY →	+0.086	+4.289	<.001	.007	3	2
BLCA	FAM247B →	+0.721	+3.423	<.001	.006	3	2
SKCM	MYCLP1 →	+0.037	+4.564	.004	.001	3	2
SKCM	ZNF25-DT →	+0.070	+4.208	.006	.003	3	2
UCEC	CD24P1 →	+0.258	+2.382	<.001	.003	3	2
BRCA	IGKV2-23 →	+0.136	+5.259	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 547 associations by consensus.

VCY by NSMCE1 expression — BLCA

Explore this box plot interactively →