family with sequence similarity 247 member BGenealiases: []
Q-omics provides the consensus-scored FAM247B profile across patient tissues and cancer cell-line models. FAM247B expression is associated with patient survival in 14 of 34 cancer types, with the highest sampling consensus in LUAD. Among the 18 cancer types available for tumor–normal comparison, FAM247B is differentially expressed in 5, with the highest sampling consensus in THCA. Additionally, FAM247B RNA expression shows 10,663 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight LUAD, THCA, and TGCT as cancer lineages where FAM247B shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for FAM247B — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes FAM247B survival associations across molecular data types. FAM247B RNA expression shows survival associations in the most cancer types (14). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible FAM247B RNA expression–survival associations across cancer types. High FAM247B expression shows unfavorable associations in ACC, LIHC and COAD, but favorable associations in LUAD, BRCA and KIRP. The LUAD Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify LUAD as the clearest survival context for FAM247B RNA expression.
This table summarizes FAM247B tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 5. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for FAM247B. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. FAM247B shows lower tumor expression in KIRC, KICH, LIHC and CHOL and higher tumor expression in THCA. The THCA box plot shows higher FAM247B RNA expression in tumor versus normal tissue (log2 FC = +1.957, t-test p < 0.001).
This table shows molecular features associated with FAM247B in patient tissues and cancer cell lines. In patient samples, FAM247B shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set.
