Q-omics provides the consensus-scored IGKV2-23 profile across patient tissues and cancer cell-line models. IGKV2-23 expression is associated with patient survival in 13 of 34 cancer types, with the highest sampling consensus in ESCA. Additionally, IGKV2-23 RNA expression shows 5,997 significant gene co-expression associations, with the highest sampling consensus in LAML. Together, these results highlight ESCA, and LAML as cancer lineages where IGKV2-23 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

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Survival associations

This table summarizes IGKV2-23 survival associations across molecular data types. IGKV2-23 RNA expression shows survival associations in the most cancer types (13). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

IGKV2-23 data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	13	KIRC (36)	view →

This table ranks reproducible IGKV2-23 RNA expression–survival associations across cancer types. High IGKV2-23 expression shows unfavorable associations in PCPG, HNSC, KIRC, STAD and COAD, but favorable associations in ESCA. The ESCA Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .015). Together, the overview and detailed table identify ESCA as the clearest survival context for IGKV2-23 RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Tertile	III,IV	1.000	0.269	.015	36	view →
PCPG	DFS	Tertile	All	0.063	0.861	<.001	36	view →
HNSC	OS	Tertile	III,IV	0.189	0.679	.001	36	view →
KIRC	DFS	Tertile	IV	0.127	0.619	.008	36	view →
STAD	DFS	Tertile	All	0.215	0.430	.004	33	view →
COAD	OS	Tertile	III,IV	0.163	0.791	.004	27	view →

Pink = unfavorable, green = favorable. all 13 lineages →

IGKV2-23-ESCA (DFS)

Kaplan–Meier survival curve for IGKV2-23 RNA expression in ESCA: high vs low expression groups.

Explore this curve interactively →

Cross-omics associations

This table shows molecular features associated with IGKV2-23 in patient tissues and cancer cell lines. In patient samples, IGKV2-23 shows the broadest associations at the RNA and protein expression levels, with LAML recurring as the lineage with the largest associated feature set.

Associated data type	Strength (# associated data)	Lineage of highest associated data
▼RNA
RNA	5,997	LAML (1512)	view →
Function (RNA)	5,944	STAD (5076)	view →