IGKV2-23

Across TCGA patient cohorts, IGKV2-23 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,944 significant associations in total. STAD shows the largest number of these associations.

The most reproducible IGKV2-23-associated GO terms across cancer lineages are Regulation of B cell proliferation, B cell activation, and B cell mediated immunity. Each is linked with IGKV2-23 in more than 11 cancer types. Because this analysis shows association rather than direction, both IGKV2-23-to-partner and partner-to-IGKV2-23 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of B cell proliferation grouped by IGKV2-23-low versus IGKV2-23-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (IGKV2-23→partner) and Y-score (partner→IGKV2-23) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of B cell proliferation →	+0.099	+0.052	<.001	<.001	3	12
STAD	B cell activation →	+0.114	+0.055	<.001	<.001	3	11
STAD	B cell mediated immunity →	+0.120	+0.076	<.001	<.001	3	11
STAD	Regulation of CD4-positive, alpha-beta T cell activation →	+0.089	+0.056	<.001	<.001	3	11
STAD	Mature B cell differentiation →	+0.100	+0.108	<.001	<.001	3	11
STAD	T-helper 1 type immune response →	+0.087	+0.068	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,944 associations by consensus.

Regulation of B cell proliferation by IGKV2-23 expression — STAD

Explore this box plot interactively →