IGKV2-23

Across TCGA pan-cancer cohorts, IGKV2-23 RNA is linked to patient survival in 13 of 34 cancer types, making it the most broadly survival-associated IGKV2-23 data layer.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher IGKV2-23 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated IGKV2-23 expression acts as an unfavorable survival marker, although some lineages such as ESCA and LUAD show a favorable association.

ESCA, KIRC, and PCPG are the cancer types where IGKV2-23 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	DFS	Tertile	III,IV	1.000	0.269	.015	36	view →
KIRC	DFS	Tertile	IV	0.127	0.619	.008	36	view →
PCPG	DFS	Tertile	All	0.063	0.861	<.001	36	view →
HNSC	OS	Tertile	III,IV	0.189	0.679	.001	36	view →
STAD	DFS	Tertile	All	0.215	0.430	.004	33	view →
COAD	OS	Tertile	III,IV	0.163	0.791	.004	27	view →
READ	OS	Tertile	All	0.069	0.910	<.001	27	view →
LUAD	OS	Tertile	IV	0.511	0.378	.009	24	view →
OV	OS	Tertile	All	1.000	0.684	.045	12	view →
LIHC	DFS	Tertile	II,III,IV	0.124	0.469	.017	9	view →
LAML	DFS	Median	All	0.473	0.271	.008	8	view →
THCA	OS	Tertile	II,III,IV	0.843	0.987	.024	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 13 lineages.

IGKV2-23–ESCA (DFS)

Open the ESCA breakdown →