NRP1

Across TCGA cell cohorts, NRP1 mutation is significantly associated with the RNA expression of many other genes, with 380 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NRP1-associated genes across cancer lineages are VCY1B, DMRTB1, and KRTAP9-1. Each is linked with NRP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NRP1-to-partner and partner-to-NRP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VCY1B grouped by NRP1-low versus NRP1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NRP1→partner) and Y-score (partner→NRP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	VCY1B →	+1.156	+3.736	<.001	.009	3	1
BLOOD_Lymphoma	DMRTB1 →	+0.021	+3.714	<.001	.006	3	1
BLOOD_Lymphoma	KRTAP9-1 →	+0.032	+4.662	<.001	.003	3	1
LUNG_SCLC	SPRR4 →	+0.057	+4.643	<.001	.004	3	1
LUNG_SCLC	TEX43 →	+0.191	+4.523	<.001	.003	3	1
LUNG_SCLC	SPRR5 →	+0.352	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 380 associations by consensus.

VCY1B by NRP1 expression — BLOOD_Lymphoma

Explore this box plot interactively →