NRP1

Across TCGA pan-cancer cohorts, NRP1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of NRP1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where NRP1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NRP1 is over-expressed in tumor, although a few such as LUSC and UCEC show the opposite, repressed pattern.

KIRC, LUSC, and HNSC are the cancer types where NRP1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NRP1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+1.432	<.001	11	view →
LUSC	Female	II,III,IV	−1.677	<.001	9	view →
HNSC	Female	All	+1.172	<.001	9	view →
LIHC	Female	II,III,IV	+1.123	<.001	7	view →
UCEC	All	All	−1.705	<.001	6	view →
STAD	All	II,III,IV	+0.991	.001	6	view →
BRCA	All	III,IV	−0.736	<.001	6	view →
KICH	Female	All	−1.715	<.001	5	view →
COAD	Female	All	−0.552	.017	3	view →
CHOL	All	All	+1.924	.002	2	view →
READ	Female	All	−1.145	.034	1	view →
ESCA	All	All	+1.139	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

NRP1–KIRC

Open the KIRC breakdown →