NPTN

Across TCGA patient cohorts, NPTN mutation is significantly associated with the RNA expression of many other genes, with 3,494 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPTN-associated genes across cancer lineages are MTND5P29, RN7SL565P, and RNA5SP129. Each is linked with NPTN in more than 1 cancer types. Because this analysis shows association rather than direction, both NPTN-to-partner and partner-to-NPTN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND5P29 grouped by NPTN-low versus NPTN-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPTN→partner) and Y-score (partner→NPTN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MTND5P29 →	+0.031	+4.812	<.001	.006	3	2
BLCA	RN7SL565P →	+0.209	+7.640	<.001	.009	3	2
CESC	RNA5SP129 →	+0.353	+4.503	.001	.005	3	2
SKCM	RN7SL316P →	+0.519	+3.915	<.001	.002	3	2
LUSC	COX6A1P3 →	+0.193	+4.984	.003	.009	3	2
LGG	USP9YP10 →	+0.049	+7.977	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,494 associations by consensus.

MTND5P29 by NPTN expression — CESC

Explore this box plot interactively →