NPL

Across TCGA patient cohorts, NPL mutation is significantly associated with the RNA expression of many other genes, with 1,836 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible NPL-associated genes across cancer lineages are RNU6-1258P, RNA5SP161, and RNU6-1214P. Each is linked with NPL in more than 1 cancer types. Because this analysis shows association rather than direction, both NPL-to-partner and partner-to-NPL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1258P grouped by NPL-low versus NPL-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPL→partner) and Y-score (partner→NPL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU6-1258P →	+0.393	+7.640	<.001	.009	3	2
UCEC	RNA5SP161 →	+0.753	+2.528	<.001	<.001	3	2
CESC	RNU6-1214P →	+0.355	+5.306	<.001	.006	3	1
CESC	RNU6-108P →	+0.410	+5.306	<.001	.006	3	1
CESC	MIR7-3 →	+0.370	+6.342	<.001	.001	3	1
CESC	DNMT3AP1 →	+0.030	+5.418	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,836 associations by consensus.

RNU6-1258P by NPL expression — BLCA

Explore this box plot interactively →