NPL

Across TCGA pan-cancer cohorts, NPL RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated NPL data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher NPL RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated NPL expression acts as an unfavorable survival marker, although some lineages such as CESC and LUSC show a favorable association.

CESC, LGG, and ACC are the cancer types where NPL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Tertile	All	0.888	0.693	<.001	80	view →
LGG	DFS	Median	All	0.654	0.814	<.001	45	view →
ACC	OS	Tertile	II,III,IV	0.718	1.000	.003	45	view →
LIHC	OS	Tertile	All	0.578	0.775	<.001	44	view →
LUSC	DFS	Median	All	0.714	0.572	.001	35	view →
HNSC	DFS	Tertile	IV	0.742	0.564	.005	32	view →
THYM	DFS	Tertile	All	0.544	1.000	.005	25	view →
LUAD	OS	Median	II,III,IV	0.786	0.632	<.001	24	view →
KIRC	DFS	Median	III,IV	0.809	0.674	.008	17	view →
CHOL	DFS	Quartile	All	1.000	0.293	.013	12	view →
ESCA	OS	Median	All	1.000	0.693	.038	12	view →
PAAD	DFS	Tertile	II,III,IV	0.543	0.339	.017	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

NPL–CESC (DFS)

Open the CESC breakdown →