NPL

Across TCGA pan-cancer cohorts, NPL RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of NPL’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NPL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NPL is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

HNSC, KIRC, and STAD are the cancer types where NPL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NPL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	IV	+1.387	<.001	12	view →
KIRC	All	II,III,IV	+0.956	<.001	8	view →
STAD	All	All	+1.005	<.001	7	view →
KICH	All	II,III,IV	−1.716	<.001	6	view →
BRCA	Female	II,III,IV	+0.444	<.001	6	view →
KIRP	Female	II,III,IV	−1.724	.012	4	view →
LUSC	Female	All	+1.094	<.001	3	view →
PAAD	All	All	−1.552	.005	2	view →
UCEC	All	All	+0.392	.025	2	view →
PRAD	All	All	−0.272	.029	2	view →
LIHC	Male	All	+0.542	.049	1	view →
COAD	Male	II,III,IV	+0.358	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

NPL–HNSC

Open the HNSC breakdown →