NPC1L1

Across TCGA cell cohorts, NPC1L1 mutation is significantly associated with the RNA expression of many other genes, with 180 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible NPC1L1-associated genes across cancer lineages are POTEI, GIPC2, and DMRTC1. Each is linked with NPC1L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NPC1L1-to-partner and partner-to-NPC1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POTEI grouped by NPC1L1-low versus NPC1L1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NPC1L1→partner) and Y-score (partner→NPC1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	POTEI →	+0.274	+3.206	.007	.006	3	2
BLOOD_Leukemia	GIPC2 →	+0.625	+3.540	<.001	.005	3	2
OVARY	DMRTC1 →	+0.032	+2.974	<.001	.006	3	2
OESOPHAGUS	KCNG4 →	+0.007	+4.857	<.001	<.001	3	1
SOFT_TISSUE	OR10V1 →	+0.042	+5.369	<.001	.004	3	1
SOFT_TISSUE	TARM1 →	+0.024	+5.369	.009	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 180 associations by consensus.

POTEI by NPC1L1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →