NPC1L1

Across TCGA pan-cancer cohorts, NPC1L1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of NPC1L1’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where NPC1L1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NPC1L1 is over-expressed in tumor, although a few such as KICH and BLCA show the opposite, repressed pattern.

COAD, KICH, and BLCA are the cancer types where NPC1L1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NPC1L1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	All	+0.990	<.001	9	view →
KICH	All	II,III,IV	−0.744	<.001	7	view →
BLCA	Male	IV	−0.644	<.001	7	view →
LUAD	All	All	+0.488	<.001	7	view →
UCEC	All	All	−0.235	.026	4	view →
LIHC	Female	All	−2.030	<.001	3	view →
HNSC	Female	All	−0.186	.003	3	view →
LUSC	All	All	+0.112	.015	2	view →
KIRP	Male	All	−0.524	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

NPC1L1–COAD

Open the COAD breakdown →