NOBOX

Across TCGA patient cohorts, NOBOX protein abundance is significantly associated with the RNA expression of many other genes, with 1,298 significant associations in total. GBM shows the largest number of these associations.

The most reproducible NOBOX-associated genes across cancer lineages are DMC1, CHADL, and GPR143. Each is linked with NOBOX in more than 1 cancer types. Because this analysis shows association rather than direction, both NOBOX-to-partner and partner-to-NOBOX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, NOBOX versus DMC1 in LSCC, with a Pearson correlation of 0.71.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOBOX→partner) and Y-score (partner→NOBOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DMC1 →	+1.285	+1.793	.001	.008	3	1
LSCC	CHADL →	+1.119	+2.074	<.001	.005	3	1
LSCC	GPR143 →	+1.619	+1.414	.003	.007	3	1
LSCC	AAGAB →	+0.937	+2.077	<.001	.005	3	1
LSCC	VPS18 →	+0.509	+2.255	.004	.008	3	1
LSCC	DVL1 →	+1.025	+2.367	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,298 associations by consensus.

NOBOX vs DMC1 — LSCC

Explore this scatter interactively →