NOBOX

Across TCGA pan-cancer cohorts, NOBOX RNA is linked to patient survival in 14 of 34 cancer types, making it the most broadly survival-associated NOBOX data layer compared with 3 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher NOBOX RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NOBOX expression acts as an unfavorable survival marker, although some lineages such as UCS and LUSC show a favorable association.

SCLC, KIRC, and UCS are the cancer types where NOBOX RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Tertile	IV	0.137	0.548	.004	72	view →
KIRC	DFS	Quartile	IV	0.273	0.681	.002	52	view →
UCS	OS	Median	II,III,IV	0.805	0.460	.007	30	view →
MESO	OS	Tertile	II,III,IV	0.264	0.591	.001	27	view →
LUSC	OS	Tertile	III,IV	0.699	0.435	.014	25	view →
SKCM	OS	Tertile	IV	0.179	0.727	<.001	18	view →
LUAD	OS	Tertile	IV	0.114	0.560	.038	18	view →
KIRP	OS	Median	III,IV	0.834	0.507	.002	17	view →
BLCA	OS	Tertile	IV	0.252	0.607	.012	9	view →
READ	DFS	Tertile	IV	0.095	0.697	.014	9	view →
BRCA	DFS	Tertile	II,III,IV	0.922	0.943	.038	6	view →
HNSC	OS	Tertile	All	0.834	0.740	.024	4	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 14 lineages.

NOBOX–SCLC (OS)

Open the SCLC breakdown →