NOBOX

RNA — tumor vs normal
Tumor vs NormalRNABox plot · TCGA cohorts

Across TCGA pan-cancer cohorts, NOBOX RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of NOBOX’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where NOBOX RNA is more highly expressed in tumor relative to normal tissue. In most cancer types NOBOX is over-expressed in tumor.

HNSC and LUSC are the cancer types where NOBOX tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in NOBOX RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.
LineageGenderStageFold-changepSampling consensus
HNSCAllAll+0.580.0134view →
LUSCAllAll+0.080.0082view →
Pink = over-expressed in tumor, green = repressed in tumor. Showing the 2 strongest of 2 lineages.

NOBOX–HNSC

Tumor-vs-normal expression box plot for NOBOX RNA in HNSC.

Open the HNSC breakdown →

Exploration