NOB1

Across TCGA patient cohorts, NOB1 mutation is significantly associated with the RNA expression of many other genes, with 120 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible NOB1-associated genes across cancer lineages are ASS1P6, LINC02654, and KRT18P45. Each is linked with NOB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both NOB1-to-partner and partner-to-NOB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASS1P6 grouped by NOB1-low versus NOB1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (NOB1→partner) and Y-score (partner→NOB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ASS1P6 →	+0.039	+4.553	.002	.005	3	2
BRCA	LINC02654 →	+0.060	+5.382	<.001	.003	3	2
UCEC	KRT18P45 →	+0.083	+3.061	.001	.002	3	2
SKCM	RNU6-1273P →	+0.119	+4.485	<.001	.004	3	2
SKCM	SNORA46 →	+0.422	+3.698	.005	.002	3	2
BLCA	RNU6-460P →	+0.611	+3.715	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 120 associations by consensus.

ASS1P6 by NOB1 expression — BRCA

Explore this box plot interactively →