NOB1

Across TCGA pan-cancer cohorts, NOB1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated NOB1 data layer compared with 4 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher NOB1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated NOB1 expression acts as an unfavorable survival marker, although some lineages such as KIRC and UVM show a favorable association.

HNSC, ACC, and LIHC are the cancer types where NOB1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.700	0.815	<.001	109	view →
ACC	DFS	Median	All	0.257	0.637	<.001	87	view →
LIHC	OS	Quartile	All	0.525	0.777	<.001	67	view →
LUAD	DFS	Median	All	0.744	0.876	.001	63	view →
PAAD	DFS	Median	All	0.383	0.581	<.001	45	view →
KIRC	DFS	Quartile	All	0.904	0.705	.001	38	view →
UVM	DFS	Tertile	All	0.876	0.537	.005	20	view →
KIRP	DFS	Quartile	All	0.823	0.957	.001	20	view →
BRCA	OS	Quartile	III,IV	0.723	0.410	.005	14	view →
SCLC	OS	Median	All	1.000	0.520	.005	10	view →
THYM	DFS	Median	All	0.884	0.622	.002	10	view →
THCA	DFS	Median	IV	0.640	0.984	.008	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

NOB1–HNSC (OS)

Open the HNSC breakdown →